Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity
Joint Authors
Md, Shadab
Alhakamy, Nabil A.
Akhter, Sohail
Awan, Zuhier A. Y.
Aldawsari, Hibah M.
Alharbi, Waleed S.
Haque, Anzarul
Choudhury, Hira
Sivakumar, Ponnurengam Malliappan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nanosuspensions are widely reported to enhance the solubility of poorly soluble drugs.
In addition to enhancement in solubility, improvement of stability and therapeutic efficacy would be an added advantage.
In the present study, premilling and subsequent high-pressure homogenization were carried out to produce naringenin nanosuspension.
Hydroxypropyl methylcellulose and sodium dodecyl sulfate were evaluated for their performance as stabilizers under various homogenization cycles.
The prepared nanosuspensions were studied for average particle size and size distribution, zeta potential, solubility, drug release, antioxidant activity, and in vitro antitumor activity.
It was observed that both hydroxypropyl methylcellulose-stabilized nanosuspension and sodium dodecyl sulfate-stabilized nanosuspension produced an enhancement in physical stability, antioxidant potential, and in vitro cytotoxicity compared with naringenin.
Furthermore, hydroxypropyl methylcellulose-stabilized nanosuspension was found to be better than sodium dodecyl sulfate-stabilized nanosuspension in terms of particle size and size distribution, storage stability, and drug release.
This study showed that nanosuspension formulations could be a potential strategy for improving dissolution and antitumor activity of naringenin.
American Psychological Association (APA)
Md, Shadab& Alhakamy, Nabil A.& Akhter, Sohail& Awan, Zuhier A. Y.& Aldawsari, Hibah M.& Alharbi, Waleed S.…[et al.]. 2020. Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1181622
Modern Language Association (MLA)
Md, Shadab…[et al.]. Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity. Journal of Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1181622
American Medical Association (AMA)
Md, Shadab& Alhakamy, Nabil A.& Akhter, Sohail& Awan, Zuhier A. Y.& Aldawsari, Hibah M.& Alharbi, Waleed S.…[et al.]. Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1181622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181622