Fundamentals and Methods for T- and B-Cell Epitope Prediction
Joint Authors
Sanchez-Trincado, Jose L.
Gomez-Perosanz, Marta
Reche, Pedro A.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
Memory and effector functions of B- and T-cells are predicated on the recognition through specialized receptors of specific targets (antigens) in pathogens.
More specifically, B- and T-cells recognize portions within their cognate antigens known as epitopes.
There is great interest in identifying epitopes in antigens for a number of practical reasons, including understanding disease etiology, immune monitoring, developing diagnosis assays, and designing epitope-based vaccines.
Epitope identification is costly and time-consuming as it requires experimental screening of large arrays of potential epitope candidates.
Fortunately, researchers have developed in silico prediction methods that dramatically reduce the burden associated with epitope mapping by decreasing the list of potential epitope candidates for experimental testing.
Here, we analyze aspects of antigen recognition by T- and B-cells that are relevant for epitope prediction.
Subsequently, we provide a systematic and inclusive review of the most relevant B- and T-cell epitope prediction methods and tools, paying particular attention to their foundations.
American Psychological Association (APA)
Sanchez-Trincado, Jose L.& Gomez-Perosanz, Marta& Reche, Pedro A.. 2017. Fundamentals and Methods for T- and B-Cell Epitope Prediction. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1181637
Modern Language Association (MLA)
Sanchez-Trincado, Jose L.…[et al.]. Fundamentals and Methods for T- and B-Cell Epitope Prediction. Journal of Immunology Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1181637
American Medical Association (AMA)
Sanchez-Trincado, Jose L.& Gomez-Perosanz, Marta& Reche, Pedro A.. Fundamentals and Methods for T- and B-Cell Epitope Prediction. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1181637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181637