Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10
Joint Authors
Xing, Xin
Zhang, Zhigang
Wang, Ya-Hui
Li, Rong-Kun
Fu, Ying
Li, Jun
Yang, Xiao-Mei
Zhang, Yan-Li
Zhu, Lei
Yang, Qin
Gu, Jian-Ren
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Exemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer.
Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antioxidant activities which are all involved in hepatic fibrosis.
Therefore, we investigated the role of EXE during the progress of hepatic fibrosis.
The effect of EXE on liver injury and fibrosis were assessed in two hepatic fibrosis rat models, which were induced by either carbon tetrachloride (CCl4) or bile duct ligation (BDL).
The influence of EXE treatment on activation and proliferation of primary rat hepatic stellate cells (HSCs) was observed in vitro.
The results showed that EXE attenuated the liver fibrosis by decreasing the collagen deposition and α-SMA expression in vivo and inhibited the activation and proliferation of primary rat HSCs in vitro.
Additionally, EXE promoted the secretion of antifibrotic and anti-inflammatory cytokine IL-10 in vivo and in HSC-T6 culture media.
In conclusion, our findings reveal a new function of EXE on hepatic fibrosis and prompted its latent application in liver fibrotic-related disease.
American Psychological Association (APA)
Wang, Ya-Hui& Li, Rong-Kun& Fu, Ying& Li, Jun& Yang, Xiao-Mei& Zhang, Yan-Li…[et al.]. 2017. Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181667
Modern Language Association (MLA)
Wang, Ya-Hui…[et al.]. Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181667
American Medical Association (AMA)
Wang, Ya-Hui& Li, Rong-Kun& Fu, Ying& Li, Jun& Yang, Xiao-Mei& Zhang, Yan-Li…[et al.]. Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181667