Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis
Joint Authors
Ota, Masao
Umemura, Takeji
Joshita, Satoru
Tanaka, Eiji
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies.
Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases.
Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades.
Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens.
In this review, we describe the influence of HLA alleles and other gene polymorphisms on PBC along with the results of genome-wide association studies (GWAS) on this disease.
American Psychological Association (APA)
Joshita, Satoru& Umemura, Takeji& Tanaka, Eiji& Ota, Masao. 2017. Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181676
Modern Language Association (MLA)
Joshita, Satoru…[et al.]. Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis. Journal of Immunology Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1181676
American Medical Association (AMA)
Joshita, Satoru& Umemura, Takeji& Tanaka, Eiji& Ota, Masao. Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181676