Manipulation of Innate and Adaptive Immunity through Cancer Vaccines
Joint Authors
Sayour, Elias J.
Mitchell, Duane A.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically.
Cross talk between the innate and adaptive immune response may be requisite to polarize sustained antigen specific immunity.
Cancer vaccines can serve as an essential fulcrum in initiating innate immunity while molding and sustaining adaptive immunity.
Although peptide vaccines have shown tepid responses in a therapeutic setting with poor correlates for immune activity, RNA vaccines activate innate immune responses and have shown promising effects in preclinical and clinical studies based on enhanced DC migration.
While the mechanistic insights behind the interplay between innate and adaptive immunity may be unique to the immunotherapeutic being investigated, understanding this dynamic is important to coordinate the different arms of the immune response in a focused response against cancer antigens.
American Psychological Association (APA)
Sayour, Elias J.& Mitchell, Duane A.. 2017. Manipulation of Innate and Adaptive Immunity through Cancer Vaccines. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181682
Modern Language Association (MLA)
Sayour, Elias J.& Mitchell, Duane A.. Manipulation of Innate and Adaptive Immunity through Cancer Vaccines. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181682
American Medical Association (AMA)
Sayour, Elias J.& Mitchell, Duane A.. Manipulation of Innate and Adaptive Immunity through Cancer Vaccines. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181682