The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy
Joint Authors
Chen, Xinhua
Meng, Xueqin
Wu, Liming
Zheng, Shusen
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The overuse of glucocorticoid may cause the metabolic disorders affecting the long term outcome of liver transplantation.
This study aims to investigate the immune adjustment strategy by decreasing use of glucocorticoid after liver transplantation.
The follow-up study was carried out on liver function and lipid metabolism.
This study included adult recipients of liver transplantation.
There were 3 groups according to their use of glucocorticoid: long term (>3 months, n=18), short term (<3 months, n=20), and control group (no use of glucocorticoid, radical hepatic resection, n=22).
The laboratory results of liver function (AST/ALT ratio) and serum lipid were compared 6 months after liver transplantation.
AST/ALT ratio, the marker of liver function, showed no significant difference between long and short term group (P>0.05).
The acute rejection had no significant difference between short and long term groups, while TG, HDL, LDL, and glucose showed significant change in the long term group (P<0.05).
At 6 months after liver transplantation, the long term group showed higher metabolic disorders (P<0.05).
The proper immune adjustment strategy should be made to avoid overuse of glucocorticoid.
It can decrease hyperlipidemia and other metabolic disorders after liver transplantation without increasing the acute rejection or liver function damage.
American Psychological Association (APA)
Meng, Xueqin& Chen, Xinhua& Wu, Liming& Zheng, Shusen. 2017. The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181686
Modern Language Association (MLA)
Meng, Xueqin…[et al.]. The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy. Journal of Immunology Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1181686
American Medical Association (AMA)
Meng, Xueqin& Chen, Xinhua& Wu, Liming& Zheng, Shusen. The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181686