Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease
Joint Authors
Kotarski, Jan
Gałczyński, Krzysztof
Rechberger, Tomasz
Adamiak-Godlewska, Aneta
Romanek-Piva, Katarzyna
Gogacz, Marek
Wojtaś, Małgorzata
Winkler, Izabela
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent studies of the peritoneal cavity environment in endometriosis demonstrate quantitative and qualitative changes in the cells responsible for cell-mediated immunity.
Such changes may have led to disturbances in the surveillance, recognition, and destruction of misplaced endometrial cells and might have, in fact, brought about the disease.
The aim of the study was to assess CD95 (Fas) expression on (activated) peritoneal fluid (PF) macrophages, as well as to ascertain soluble Fas (sFas) concentration in the PF of endometriosis patients, as compared to the nonendometriotic group.
The concentration of leukocytes in the PF, the percentage of cells expressing CD45+/CD14+, and the percentage of PF macrophages expressing the HLA-DR antigen were significantly higher in patients with stages I and II endometriosis.
The percentage of Fas- (CD95+-) expressing macrophages was significantly higher in all stages of the disease, in comparison with controls.
Moreover, the concentration of sFas in the PF of patients with moderate and severe endometriosis was significantly higher, as compared to the reference group.
The high number of immune cells in PF in early stage endometriosis and their increased susceptibility to apoptosis confirm the role of the impaired peritoneal environment and immune defects in the development and progression of the disease.
American Psychological Association (APA)
Gogacz, Marek& Gałczyński, Krzysztof& Wojtaś, Małgorzata& Winkler, Izabela& Adamiak-Godlewska, Aneta& Romanek-Piva, Katarzyna…[et al.]. 2017. Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181689
Modern Language Association (MLA)
Gogacz, Marek…[et al.]. Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181689
American Medical Association (AMA)
Gogacz, Marek& Gałczyński, Krzysztof& Wojtaś, Małgorzata& Winkler, Izabela& Adamiak-Godlewska, Aneta& Romanek-Piva, Katarzyna…[et al.]. Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181689