Gold Nanoparticles Suppressed Proliferation, Migration, and Invasion in Papillary Thyroid Carcinoma Cells via Downregulation of CCT3
Joint Authors
Liu, Fangzhou
Ma, Dawei
Chen, Wei
Chen, Xinyuan
Qian, Yichun
Zhao, Yanbin
Hu, Tingting
Yin, Rong
Zhu, Yan
Zhang, Yu
Zhang, Yuan
Zhao, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Emerging evidences have demonstrated that gold nanoparticles (AuNPs) have been used for cancer treatment.
The aim of this study was to investigate the effects and molecular mechanisms of AuNPs on papillary thyroid carcinoma (PTC) cells (BCPAP and TPC-1).
Characterizations of AuNPs were detected by UV-Vis spectra, transmission electron microscopy (TEM), and dynamic light scattering (DLS).
Cell proliferation and apoptosis, migration, and invasion of PTC cells were evaluated by MTT, flow cytometry, wound healing, and transwell assays, respectively.
Furthermore, qRT-PCR and western blot assays were performed to assess the protein expressions related to apoptosis and migration including caspase-3, caspase-9, Bax, Bcl-2, MMP-2, and MMP-9.
The study revealed that AuNPs significantly suppressed cell viability, migration, and invasion and remarkably induced apoptosis of BCPAP and TPC-1 cells compared with the control group.
Moreover, AuNPs negatively regulated the expression of CCT3 and silencing of CCT3 obviously promoted the proliferation, migration, and invasion inhibition and apoptosis induction of PTC cells combined with AuNPs.
Collectively, these results highlighted the potential application of AuNPs in PTC target therapy.
American Psychological Association (APA)
Liu, Fangzhou& Ma, Dawei& Chen, Wei& Chen, Xinyuan& Qian, Yichun& Zhao, Yanbin…[et al.]. 2019. Gold Nanoparticles Suppressed Proliferation, Migration, and Invasion in Papillary Thyroid Carcinoma Cells via Downregulation of CCT3. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1181698
Modern Language Association (MLA)
Liu, Fangzhou…[et al.]. Gold Nanoparticles Suppressed Proliferation, Migration, and Invasion in Papillary Thyroid Carcinoma Cells via Downregulation of CCT3. Journal of Nanomaterials No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1181698
American Medical Association (AMA)
Liu, Fangzhou& Ma, Dawei& Chen, Wei& Chen, Xinyuan& Qian, Yichun& Zhao, Yanbin…[et al.]. Gold Nanoparticles Suppressed Proliferation, Migration, and Invasion in Papillary Thyroid Carcinoma Cells via Downregulation of CCT3. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1181698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181698