HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined
Joint Authors
Jucaud, Vadim
El-Awar, Nadim
Nguyen, Anh
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Sensitization to human leukocyte antigens (HLA) in organ transplant patients causes graft rejection, according to the humoral theory of transplantation.
Sensitization is almost ubiquitous as anti-HLA antibodies are found in almost all sera of transplant recipients.
Advances in testing assays and amino acid sequencing of HLA along with computer software contributed further to the understanding of antibody-antigen reactivity.
It is commonly understood that antibodies bind to HLA antigens.
With current knowledge of epitopes, it is more accurate to describe that antibodies bind to their target epitopes on the surface of HLA molecular chains.
Epitopes are present on a single HLA (private epitope) or shared by multiple antigens (public epitope).
The phenomenon of cross-reactivity in HLA testing, often explained as cross-reactive groups (CREGs) of antigens with antibody, can be clearly explained now by public epitopes.
Since 2006, we defined and reported 194 HLA class I unique epitopes, including 56 cryptic epitopes on dissociated HLA class I heavy chains, 83 HLA class II epitopes, 60 epitopes on HLA-DRB1, 15 epitopes on HLA-DQB1, 3 epitopes on HLA-DQA1, 5 epitopes on HLA-DPB1, and 7 MICA epitopes.
In this paper, we provide a summary of our findings.
American Psychological Association (APA)
El-Awar, Nadim& Jucaud, Vadim& Nguyen, Anh. 2017. HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1181703
Modern Language Association (MLA)
El-Awar, Nadim…[et al.]. HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined. Journal of Immunology Research No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1181703
American Medical Association (AMA)
El-Awar, Nadim& Jucaud, Vadim& Nguyen, Anh. HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1181703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181703