Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6lpr Mice
Joint Authors
Huang, Zhaofeng
Zhou, Xiaoqing
Chen, Huanpeng
Su, Qiao
Xu, Xiaoxie
Huang, Jun
Zhao, Mei
Mo, Jinhua
Yu, Bolan
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease mainly caused by the defect of Fas-mediated apoptosis and characterized by nonmalignant autoimmune lymphoproliferation.
Stabilized β-catenin could not only potentiate Fas-mediated T cell apoptosis via upregulating the expression of Fas on activated T cells, but also potentiate T cell apoptosis via intrinsic apoptotic pathway.
In the present study, we introduced β-catTg into lpr/lpr mice and aimed to explore the potential role of stabilized β-catenin (β-catTg) in the development of ALPS-like phenotypes of lpr/lpr mice.
We found that the total splenocyte cells and some compositions were slightly downregulated in β-catTglpr/lpr mice, especially the CD4 and CD8 TEM cells were significantly reduced.
Meanwhile, stabilized β-catenin obviously decreased the numbers of spleen TCRβ+CD4−CD8− T (DNT) cells, and the levels of some serum proinflammatory factors also were lowered in β-catTglpr/lpr mice.
Beyond that, stabilized β-catenin slightly lowered the levels of the serum autoantibodies and the scores of kidney histopathology of β-catTglpr/lpr mice compared with lpr/lpr mice.
Our study suggested that stabilized β-catenin ameliorated some ALPS-like symptoms of lpr/lpr mice by potentiating Fas-independent signal-mediated T cell apoptosis, which might uncover a potential novel therapeutic direction for ALPS.
American Psychological Association (APA)
Xu, Xiaoxie& Huang, Jun& Zhao, Mei& Chen, Huanpeng& Mo, Jinhua& Zhou, Xiaoqing…[et al.]. 2017. Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6lpr Mice. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181715
Modern Language Association (MLA)
Xu, Xiaoxie…[et al.]. Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6lpr Mice. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181715
American Medical Association (AMA)
Xu, Xiaoxie& Huang, Jun& Zhao, Mei& Chen, Huanpeng& Mo, Jinhua& Zhou, Xiaoqing…[et al.]. Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6lpr Mice. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181715