Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality
Joint Authors
Li, Jih-Heng
Wang, Chia-Chi
Chen, Ih-Sheng
Cheng, Yin-Hua
Liu, Sian-De
Lin, Ying-Chi
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Neolitsea species, medicinal plants belonging to Lauraceae, contain rich alkaloids, steroids, sesquiterpenoids, and triterpenoids which possess antimicrobial, antioxidant, and anti-inflammatory bioactivities.
However, species differences in the immunomodulatory effects and evidence pertaining to the effects of Neolitsea species on adaptive immunity are scarce.
This study aimed to evaluate the immunomodulatory properties of ten Taiwanese Neolitsea plants on T helper (Th) cell functionality, especially Th1 and Th2.
Most of the 29 crude extracts of Neolitsea were not toxic to splenocytes, except N.
buisanensis roots.
N.
aciculata and N.
villosa leaf extracts possessed differential immunomodulatory effects on Th1/Th2 balance.
N.
aciculata var.
variabillima and N.
hiiranensis leaf extracts attenuated both Th1 and Th2 cytokines while N.
konishii dramatically suppressed IFN-γ production.
As N.
aciculata var.
variabillima and N.
konishii leaf extracts significantly attenuated Th1 functionality, we further evaluated their effects on CD4 cells under CD3/CD28 stimulation.
N.
aciculata var.
variabillima significantly suppressed IFN-γ, IL-10, and IL-17, demonstrating the broad suppressive effects on T helper cells; N.
konishii significantly suppressed IFN-γ and IL-10 production, while the production of IL-17 was not altered.
Collectively, these data demonstrated that leaf extracts of Taiwanese Neolitsea species contain phytochemicals with potentials to be developed as selective immunomodulators.
American Psychological Association (APA)
Cheng, Yin-Hua& Lin, Ying-Chi& Chen, Ih-Sheng& Liu, Sian-De& Li, Jih-Heng& Wang, Chia-Chi. 2017. Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1181723
Modern Language Association (MLA)
Cheng, Yin-Hua…[et al.]. Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality. Journal of Immunology Research No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1181723
American Medical Association (AMA)
Cheng, Yin-Hua& Lin, Ying-Chi& Chen, Ih-Sheng& Liu, Sian-De& Li, Jih-Heng& Wang, Chia-Chi. Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1181723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181723