Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety
Joint Authors
Bhat, Mashooq A.
Naglah, Ahmed M.
Al-Dhfyan, Abdullah
al-Omar, Mohamed A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A new series of novel Biginelli compounds, 5-benzoyl-substituted phenyl-3,4-dihydropyrimidin-2(1H)-one-1H-isoindole-1,3(2H)-dione (1−10), were synthesized from enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV), which was synthesized by refluxing 2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione (III), with dimethylformamide-dimethylacetal (DMF-DMA) without solvent for 12 h.
The compound 2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione (III) was obtained by reacting phthalic anhydride (I) with para-aminoacetophenone (II) in glacial acetic acid for 2 h.
The dihydropyrimidinone derivatives containing phthalimide moiety (1–10) were obtained by reacting enaminone, 2-{4-[(2E)-3-(dimethylamino) prop-2-enoyl] phenyl}-1H-isoindole-1,3(2H)-dione (IV), with urea and different substituted benzaldehydes in the presence of glacial acetic acid for 3 h.
Simple and efficient method was employed to synthesize the dihydropyrimidinone derivatives containing phthalimide moiety.
Structures of all the synthesized compounds were characterized by spectroscopic methods.
American Psychological Association (APA)
Bhat, Mashooq A.& al-Omar, Mohamed A.& Naglah, Ahmed M.& Al-Dhfyan, Abdullah. 2020. Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1181734
Modern Language Association (MLA)
Bhat, Mashooq A.…[et al.]. Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety. Journal of Chemistry No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1181734
American Medical Association (AMA)
Bhat, Mashooq A.& al-Omar, Mohamed A.& Naglah, Ahmed M.& Al-Dhfyan, Abdullah. Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1181734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181734