Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target
Joint Authors
Ying, Song-Min
Gao, Han
Dai, Yuanrong
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Asthma is a chronic inflammatory disease that undermines the airways.
It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing.
It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis.
Some patients display a neutrophil-dominant presentation and are characterized with low (or even absent) Th2 cytokines.
In recent years, increasing evidence has also suggested that neutrophils play a key role in the development of certain subtypes of asthma.
This review discusses neutrophils in asthma and potentially related targeted therapies.
American Psychological Association (APA)
Gao, Han& Ying, Song-Min& Dai, Yuanrong. 2017. Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181745
Modern Language Association (MLA)
Gao, Han…[et al.]. Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181745
American Medical Association (AMA)
Gao, Han& Ying, Song-Min& Dai, Yuanrong. Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181745