Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives
Joint Authors
Shaikh, Tanveer MahmadAlli
Debebe, Habtamu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Indole motifs are one of the most significant scaffolds in the discovery of new drugs.
We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated.
The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials.
The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method.
Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.
American Psychological Association (APA)
Shaikh, Tanveer MahmadAlli& Debebe, Habtamu. 2020. Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181747
Modern Language Association (MLA)
Shaikh, Tanveer MahmadAlli& Debebe, Habtamu. Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives. Journal of Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1181747
American Medical Association (AMA)
Shaikh, Tanveer MahmadAlli& Debebe, Habtamu. Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181747