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The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection
Joint Authors
Hamdorf, Matthias
Kawakita, Satoru
Everly, Matthew
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The control of gene expression by microRNAs (miRNAs, miR) influences many cellular functions, including cellular differentiation, cell proliferation, cell development, and functional regulation of the immune system.
Recently, miRNAs have been detected in serum, plasma, and urine and circulating miR profiles have been associated with a variety of diseases.
Rejection is one of the major causes of allograft failure and preventing and treating acute rejection are the central task for clinicians working with transplant patients.
Invasive biopsies used in monitoring rejection are burdensome and risky to transplant patients.
Novel and easily accessible biomarkers of acute rejection could make it possible to detect rejection earlier and make more fine-tuned calibration of immunosuppressive or new target treatment possible.
In this review, we discuss whether circulating miRNA can serve as an early noninvasive diagnostic biomarker and an expression fingerprint of allograft rejection and transplant failure.
Understanding the regulatory interplay of relevant miRNAs and the rejecting allograft will result in a better understanding of the molecular pathophysiology of alloimmune injury.
American Psychological Association (APA)
Hamdorf, Matthias& Kawakita, Satoru& Everly, Matthew. 2017. The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181777
Modern Language Association (MLA)
Hamdorf, Matthias…[et al.]. The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181777
American Medical Association (AMA)
Hamdorf, Matthias& Kawakita, Satoru& Everly, Matthew. The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181777