Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging
Joint Authors
Akase, Iorhen Ephraim
Musa, Bolanle O. P.
Obiako, Reginald Onyedumarakwe
Ahmad Elfulatiy, Abdurrahman
Mohammed, Abdullahi Asara
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
HIV infection is a chronic infection that almost inevitably progresses to AIDS.
The infection is characterized by the deterioration in the immune function leading to opportunistic infections and malignancies.
Additionally, there is an associated immune dysfunction characterized by a persistent inflammatory state and unhealthy elaboration of both pro- and anti-inflammatory cytokines.
The CD4+ T cell count has been used as a surrogate for the level of immune dysfunction that exists in patients with HIV infection.
Eighty-eight (88) patients with HIV infection, forty-four (44) of whom were treatment naïve patients and forty-four (44) who were treatment-experienced patients, were recruited.
The serum concentrations of cytokines IL-6 and IL-10 were carried out using R&D human Quantikine ELISA kits, while patients’ CD4+ T cell counts were evaluated using the Partec easy count kit.
The serum IL-6 and IL-10 concentrations were significantly higher among the AR-naïve participants compared to the ART-experienced group.
Additionally, the IL-6 and IL-10 concentrations were higher in patients with lower CD4+ T cell count compared to those with higher cell counts though this was not statistically significant.
Also, both IL-6 and IL-10 concentrations were higher in patients with higher WHO clinical staging of disease, significantly so for IL-6.
American Psychological Association (APA)
Akase, Iorhen Ephraim& Musa, Bolanle O. P.& Obiako, Reginald Onyedumarakwe& Ahmad Elfulatiy, Abdurrahman& Mohammed, Abdullahi Asara. 2017. Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181779
Modern Language Association (MLA)
Akase, Iorhen Ephraim…[et al.]. Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging. Journal of Immunology Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1181779
American Medical Association (AMA)
Akase, Iorhen Ephraim& Musa, Bolanle O. P.& Obiako, Reginald Onyedumarakwe& Ahmad Elfulatiy, Abdurrahman& Mohammed, Abdullahi Asara. Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181779