Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome
Joint Authors
Valesini, Guido
Truglia, Simona
Conti, Fabrizio
Capozzi, Antonella
Lococo, Emanuela
Longo, Agostina
Misasi, Roberta
Sorice, Maurizio
Manganelli, Valeria
Garofalo, Tina
De Carolis, Caterina
Alessandri, Cristiano
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pregnancy problems are common in patients with rheumatic disease; indeed, autoimmune disorders and autoantibodies can affect pregnancy progress and lead to maternal complications.
Recent studies have highlighted a close association between HMGB1, chronic inflammation, and autoimmune diseases.
Thus, in this investigation, we analyzed serum levels of HMGB1, an alarmin which plays a pivotal role in inducing and enhancing immune cell function.
Sera from 30 patients with antiphospholipid syndrome (11 primary and 19 secondary APS), 35 subjects with pregnancy morbidity, and 30 healthy women were analysed for HMGB1 and its putative receptor RAGE (sRAGE) by Western blot and for TNF-α by ELISA.
Results revealed that APS patients showed significantly increased serum levels of HMGB1, sRAGE, and the proinflammatory cytokine TNF-α, as compared to healthy women.
However, also, the pregnancy morbidity subjects showed significantly increased levels of HMGB1 and sRAGE as well as TNF-α compared to healthy women.
Our findings suggest that in subjects with pregnancy morbidity, including obstetric APS, elevated levels of HMGB1/sRAGE may represent an alarm signal, indicating an increase of proinflammatory triggers.
Further studies are needed to evaluate the role of HMGB1/sRAGE as a possible tool to evaluate the risk stratification of adverse pregnancy outcomes.
American Psychological Association (APA)
Manganelli, Valeria& Capozzi, Antonella& Truglia, Simona& Alessandri, Cristiano& Lococo, Emanuela& Garofalo, Tina…[et al.]. 2017. Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181796
Modern Language Association (MLA)
Manganelli, Valeria…[et al.]. Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181796
American Medical Association (AMA)
Manganelli, Valeria& Capozzi, Antonella& Truglia, Simona& Alessandri, Cristiano& Lococo, Emanuela& Garofalo, Tina…[et al.]. Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181796