![](/images/graphics-bg.png)
Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages
Joint Authors
Ramírez-Pacheco, Arturo
Moreno-Guerrero, Silvia Selene
Rocha-Ramírez, L. M.
Pérez-Solano, R. A.
Castañón-Alonso, S. L.
García Garibay, M.
Eslava, C.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Lactobacilli have been shown to promote health functions.
In this study, we analyzed the mechanism by which four different strains of probiotics affected innate immunity, such as regulation of ROS, cytokines, phagocytosis, bactericidal activity, signaling by NF-κB pp65, and TLR2 activation.
The production of ROS was dependent on the concentration and species of Lactobacillus.
The results obtained from the tested strains (Lactobacillus rhamnosus GG, L.
rhamnosus KLSD, L.
helveticus IMAU70129, and L.
casei IMAU60214) showed that strains induced early proinflammatory cytokines such as IL-8,TNF-α, IL-12p70, and IL-6.
However, IL-1β expression was induced only by L.
helveticus and L.
casei strains (after 24 h stimulation).
Phagocytosis and bactericidal activity of macrophages against various pathogens, such as S.
aureus, S.
typhimurium, and E.
coli, were increased by pretreatment with Lactobacillus.
The nuclear translocation NF-κB pp65 and TLR2-dependent signaling were also increased by treatment with the probiotics.
Taken together, the experiments demonstrate that probiotic strains of Lactobacillus exert early immunostimulatory effects that may be directly linked to the initial inflammation of the response of human macrophages.
American Psychological Association (APA)
Rocha-Ramírez, L. M.& Pérez-Solano, R. A.& Castañón-Alonso, S. L.& Moreno-Guerrero, Silvia Selene& Ramírez-Pacheco, Arturo& García Garibay, M.…[et al.]. 2017. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1181806
Modern Language Association (MLA)
Rocha-Ramírez, L. M.…[et al.]. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. Journal of Immunology Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1181806
American Medical Association (AMA)
Rocha-Ramírez, L. M.& Pérez-Solano, R. A.& Castañón-Alonso, S. L.& Moreno-Guerrero, Silvia Selene& Ramírez-Pacheco, Arturo& García Garibay, M.…[et al.]. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1181806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181806