Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Joint Authors

Xia, Yuchen
Cheng, Xiaoming
Blossey, Christoph K.
Wisskirchen, Karin
Esser, Knud
Protzer, Ulrike

Source

Journal of Immunology Research

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-03-06

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Interferon-α (IFN-α) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects.

In this study, we describe a novel mode of its antiviral action.

We demonstrate that the supernatant from IFN-α-treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells.

The factors contained in the supernatant competed with the virus for binding to heparan glycosaminoglycans—the nonspecific attachment step shared by HBV and HCV.

Secreted factors of high molecular mass that bind to heparin columns elicited the antiviral effect.

In conclusion, IFN-α is able to induce soluble factors that can bind to heparan glycosaminoglycans thus leading to the inhibition of viral binding.

American Psychological Association (APA)

Xia, Yuchen& Cheng, Xiaoming& Blossey, Christoph K.& Wisskirchen, Karin& Esser, Knud& Protzer, Ulrike. 2017. Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181872

Modern Language Association (MLA)

Xia, Yuchen…[et al.]. Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181872

American Medical Association (AMA)

Xia, Yuchen& Cheng, Xiaoming& Blossey, Christoph K.& Wisskirchen, Karin& Esser, Knud& Protzer, Ulrike. Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181872

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1181872