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Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro
Joint Authors
Xia, Yuchen
Cheng, Xiaoming
Blossey, Christoph K.
Wisskirchen, Karin
Esser, Knud
Protzer, Ulrike
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Interferon-α (IFN-α) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects.
In this study, we describe a novel mode of its antiviral action.
We demonstrate that the supernatant from IFN-α-treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells.
The factors contained in the supernatant competed with the virus for binding to heparan glycosaminoglycans—the nonspecific attachment step shared by HBV and HCV.
Secreted factors of high molecular mass that bind to heparin columns elicited the antiviral effect.
In conclusion, IFN-α is able to induce soluble factors that can bind to heparan glycosaminoglycans thus leading to the inhibition of viral binding.
American Psychological Association (APA)
Xia, Yuchen& Cheng, Xiaoming& Blossey, Christoph K.& Wisskirchen, Karin& Esser, Knud& Protzer, Ulrike. 2017. Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181872
Modern Language Association (MLA)
Xia, Yuchen…[et al.]. Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181872
American Medical Association (AMA)
Xia, Yuchen& Cheng, Xiaoming& Blossey, Christoph K.& Wisskirchen, Karin& Esser, Knud& Protzer, Ulrike. Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181872