TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
Joint Authors
Lefranc, Gérard
Pers, Yves-Marie
Jorgensen, Christian
Apparailly, Florence
Picard, Christophe
Khalifa, Olfa
Balandraud, Nathalie
Lambert, Nathalie
Auger, Isabelle
Roudier, Jean
Sénéchal, Audrey
Geneviève, David
Mrenda, Bakridine M’Madi
Benedito, Cécilia
Pardoux, Etienne
Gagez, Anne-Laure
Mahjoub, Touhami
Touitou, Isabelle
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA).
Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French.
The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n=408) compared with age-matched controls (n=471) in both Tunisian and French women.
These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts.
The rs1059702 C major allele was significantly associated with RA, only with French women.
In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA.
No association for these haplotypes was found in the Tunisian population.
Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women.
Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations.
American Psychological Association (APA)
Khalifa, Olfa& Balandraud, Nathalie& Lambert, Nathalie& Auger, Isabelle& Roudier, Jean& Sénéchal, Audrey…[et al.]. 2017. TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181888
Modern Language Association (MLA)
Khalifa, Olfa…[et al.]. TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181888
American Medical Association (AMA)
Khalifa, Olfa& Balandraud, Nathalie& Lambert, Nathalie& Auger, Isabelle& Roudier, Jean& Sénéchal, Audrey…[et al.]. TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181888