Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis
Joint Authors
Acosta, Armando
Chin, Kai Ling
Anis, Fadhilah Zulkipli
Sarmiento, Maria E.
Norazmi, Mohd. Nor
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb).
About one-third of the world’s population is latently infected with TB and 5–15% of them will develop active TB in their lifetime.
It is estimated that each case of active TB may cause 10–20 new infections.
Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs).
The latter that consists of IFN-γ has been associated with the promotion of Th1 immune response which is associated with protection against TB.
Although this aspect remains controversial at present due to the lack of established correlates of protection, currently, there are different prophylactic, diagnostic, and immunotherapeutic approaches in which IFNs play an important role.
This review summarizes the main aspects related with the biology of IFNs, mainly associated with TB, as well as presents the main applications of these cytokines related to prophylaxis, diagnosis, and immunotherapy of TB.
American Psychological Association (APA)
Chin, Kai Ling& Anis, Fadhilah Zulkipli& Sarmiento, Maria E.& Norazmi, Mohd. Nor& Acosta, Armando. 2017. Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181916
Modern Language Association (MLA)
Chin, Kai Ling…[et al.]. Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1181916
American Medical Association (AMA)
Chin, Kai Ling& Anis, Fadhilah Zulkipli& Sarmiento, Maria E.& Norazmi, Mohd. Nor& Acosta, Armando. Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181916