DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture

Joint Authors

Cen, Xiaomin
Yin, Geng
Xie, Qi-bing
Liang, Yan
Yang, Yuan
Yang, Min

Source

Journal of Immunology Research

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-27

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Abnormal immune response of the body against substances and tissues causes autoimmune diseases, such as polymyositis, dermatomyositis, and rheumatoid arthritis.

Irregular lipid metabolism and inflammation may be a significant cause of autoimmune diseases.

Although much progress has been made, mechanisms of initiation and proceeding of metabolic and inflammatory regulation in autoimmune disease have not been well-defined.

And novel markers for the detection and therapy of autoimmune disease are urgent.

mTOR signaling is a central regulator of extracellular metabolic and inflammatory processes, while DEP domain-containing mTOR-interacting protein (DEPTOR) is a natural inhibitor of mTOR.

Here, we report that overexpression of DEPTOR reduces mTORC1 activity in lymphocytes of human peripheral blood mononuclear cells (PBMCs).

Combination of DEPTOR overexpression and mTORC2/AKT inhibitors effectively inhibits lipogenesis and inflammation in lymphocytes of PBMC culture.

Moreover, DEPTOR knockdown activates mTORC1 and increases lipogenesis and inflammations.

Our findings provide a deep insight into the relationship between lipid metabolism and inflammations via DEPTOR-mTOR pathway and imply that DEPTOR-mTOR in lymphocytes of PBMC culture has the potential to be as biomarkers for the detection and therapies of autoimmune diseases.

American Psychological Association (APA)

Xie, Qi-bing& Liang, Yan& Yang, Min& Yang, Yuan& Cen, Xiaomin& Yin, Geng. 2017. DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181919

Modern Language Association (MLA)

Xie, Qi-bing…[et al.]. DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181919

American Medical Association (AMA)

Xie, Qi-bing& Liang, Yan& Yang, Min& Yang, Yuan& Cen, Xiaomin& Yin, Geng. DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181919

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1181919