Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma
Joint Authors
Song, Yong
Zhang, Fang
Cao, E-Hong
Xin, Xiao-Feng
Shi, Yi
Su, Xin
Huang, Gang
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Adenosine triphosphate (ATP) is a key mediator to alert the immune dysfunction by acting on P2 receptors.
Here, we found that allergen challenge caused an increase of ATP secretion in a murine model of neutrophilic asthma, which correlated well with neutrophil counts and interleukin-17 production.
When ATP signaling was blocked by intratracheal administration of the ATP receptor antagonist suramin before challenge, neutrophilic airway inflammation, airway hyperresponsiveness, and Th17-type responses were reduced significantly.
Also, neutrophilic inflammation was abrogated when airway ATP levels were locally neutralized using apyrase.
Furthermore, ATP promoted the Th17 polarization of splenic CD4+ T cells from DO11.10 mice in vitro.
In addition, ovalbumin (OVA) challenge induced neutrophilic inflammation and Th17 polarization in DO11.10 mice, whereas administration of suramin before challenge alleviated these parameters.
Thus, ATP may serve as a marker of neutrophilic asthma, and local blockade of ATP signaling might provide an alternative method to prevent Th17-mediated airway inflammation in neutrophilic asthma.
American Psychological Association (APA)
Zhang, Fang& Su, Xin& Huang, Gang& Xin, Xiao-Feng& Cao, E-Hong& Shi, Yi…[et al.]. 2017. Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181930
Modern Language Association (MLA)
Zhang, Fang…[et al.]. Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1181930
American Medical Association (AMA)
Zhang, Fang& Su, Xin& Huang, Gang& Xin, Xiao-Feng& Cao, E-Hong& Shi, Yi…[et al.]. Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181930