Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells
Joint Authors
Tang, Qingfa
Shi, Dazhi
Xu, Mengyi
Ren, Mengyue
Pan, Enshan
Luo, Chaohua
Zhang, Wei
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
This study aimed to explore the immunoregulatory effect of flavonoids of blueberry (Vaccinium corymbosum L.) leaves (FBL).
Methods.
The flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-Tof-MS).
The immunoregulatory effect and possible regulatory mechanisms of FBL were investigated in lipopolysaccharide- (LPS-) induced RAW 264.7 cells.
Results.
According to the results of UPLC/Q-Tof-MS, nine flavonoids of blueberry leaves were identified.
FBL showed a significant reduction in the production of TNF-α in LPS-stimulated RAW 264.7 cells.
FBL significantly decreased the expression of NF-κB p65 and P-NF-κB p65 in LPS-induced RAW 264.7 cells in a dose-dependent manner.
Conclusion.
Our study showed the immunoregulatory effect of FBL through the suppression of TNF-α via the NF-κB signal pathway.
American Psychological Association (APA)
Shi, Dazhi& Xu, Mengyi& Ren, Mengyue& Pan, Enshan& Luo, Chaohua& Zhang, Wei…[et al.]. 2017. Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181933
Modern Language Association (MLA)
Shi, Dazhi…[et al.]. Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181933
American Medical Association (AMA)
Shi, Dazhi& Xu, Mengyi& Ren, Mengyue& Pan, Enshan& Luo, Chaohua& Zhang, Wei…[et al.]. Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181933
