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Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
Joint Authors
Fleurence, Julien
Fougeray, Sophie
Bahri, Meriem
Cochonneau, Denis
Clémenceau, Béatrice
Paris, François
Heczey, Andras
Birklé, Stéphane
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-05
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Target selection is a key feature in cancer immunotherapy, a promising field in cancer research.
In this respect, gangliosides, a broad family of structurally related glycolipids, were suggested as potential targets for cancer immunotherapy based on their higher abundance in tumors when compared with the matched normal tissues.
GD2 is the first ganglioside proven to be an effective target antigen for cancer immunotherapy with the regulatory approval of dinutuximab, a chimeric anti-GD2 therapeutic antibody.
Although the therapeutic efficacy of anti-GD2 monoclonal antibodies is well documented, neuropathic pain may limit its application.
O-Acetyl-GD2, the O-acetylated-derivative of GD2, has recently received attention as novel antigen to target GD2-positive cancers.
The present paper examines the role of O-acetyl-GD2 in tumor biology as well as the available preclinical data of anti-O-acetyl-GD2 monoclonal antibodies.
A discussion on the relevance of O-acetyl-GD2 in chimeric antigen receptor T cell therapy development is also included.
American Psychological Association (APA)
Fleurence, Julien& Fougeray, Sophie& Bahri, Meriem& Cochonneau, Denis& Clémenceau, Béatrice& Paris, François…[et al.]. 2017. Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1181939
Modern Language Association (MLA)
Fleurence, Julien…[et al.]. Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. Journal of Immunology Research No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1181939
American Medical Association (AMA)
Fleurence, Julien& Fougeray, Sophie& Bahri, Meriem& Cochonneau, Denis& Clémenceau, Béatrice& Paris, François…[et al.]. Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1181939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181939