MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives
Joint Authors
Gioppo, Andrea
Finocchiaro, Gaetano
Bruzzone, Maria Grazia
Cuccarini, Valeria
Aquino, Domenico
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-20
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Pseudophenomena, that is, imaging alterations due to therapy rather than tumor evolution, have an important impact on the management of glioma patients and the results of clinical trials.
RANO (response assessment in neurooncology) criteria, including conventional MRI (cMRI), addressed the issues of pseudoprogression after radiotherapy and concomitant chemotherapy and pseudoresponse during antiangiogenic therapy of glioblastomas (GBM) and other gliomas.
The development of cancer immunotherapy forced the identification of further relevant response criteria, summarized by the iRANO working group in 2015.
In spite of this, the unequivocal definition of glioma progression by cMRI remains difficult particularly in the setting of immunotherapy approaches provided by checkpoint inhibitors and dendritic cells.
Advanced MRI (aMRI) may in principle address this unmet clinical need.
Here, we discuss the potential contribution of different aMRI techniques and their indications and pitfalls in relation to biological and imaging features of glioma and immune system interactions.
American Psychological Association (APA)
Aquino, Domenico& Gioppo, Andrea& Finocchiaro, Gaetano& Bruzzone, Maria Grazia& Cuccarini, Valeria. 2017. MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1181961
Modern Language Association (MLA)
Aquino, Domenico…[et al.]. MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives. Journal of Immunology Research No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1181961
American Medical Association (AMA)
Aquino, Domenico& Gioppo, Andrea& Finocchiaro, Gaetano& Bruzzone, Maria Grazia& Cuccarini, Valeria. MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1181961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181961