Study on Solubilization and Stabilization of Eight Flavonoids by 17 Chinese Herbal Polysaccharides
Joint Authors
Ren, Xiaoliang
Cao, Xuexiao
Wang, Lei
Liu, Meiqi
Han, Tingting
Deng, Yanru
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Flavonoids are important active components of traditional Chinese medicines (TCMs) because of their many biological activities.
We studied the interaction between 17 polysaccharides and eight flavonoids via high-performance liquid chromatography (HPLC) and the effect of the interactions on the solubility and stability of the flavonoids.
The effect of the polysaccharides on the solubility of flavonoids was analyzed by statistical methods and showed significant solubility improvements.
The constant temperature acceleration method (90°C/pH 9 buffer solution) was used to measure the degradation kinetics and half-life of flavonoids with and without polysaccharides.
All the polysaccharides displayed a stabilizing effect on all eight flavonoids.
The stabilizing effects varied in the order: quercetin, baicalein > baicalin > galuteolin > daidzin > rutin > luteolin > daidzien.
The phase-solubility method was applied to quercetin and baicalein to study the mechanism of action of the polysaccharides.
It appeared that the two flavonoids could form 1 : 1 inclusion complexes with polysaccharides, which may be one of the factors increasing solubility and stability.
These findings increase our understanding of the role of endogenous polysaccharides in TCM in improving the stability and bioavailability of bioactive flavonoids.
American Psychological Association (APA)
Cao, Xuexiao& Wang, Lei& Liu, Meiqi& Ren, Xiaoliang& Han, Tingting& Deng, Yanru. 2020. Study on Solubilization and Stabilization of Eight Flavonoids by 17 Chinese Herbal Polysaccharides. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1182000
Modern Language Association (MLA)
Cao, Xuexiao…[et al.]. Study on Solubilization and Stabilization of Eight Flavonoids by 17 Chinese Herbal Polysaccharides. Journal of Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1182000
American Medical Association (AMA)
Cao, Xuexiao& Wang, Lei& Liu, Meiqi& Ren, Xiaoliang& Han, Tingting& Deng, Yanru. Study on Solubilization and Stabilization of Eight Flavonoids by 17 Chinese Herbal Polysaccharides. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1182000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182000