Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin
Joint Authors
Enríquez-Medrano, Francisco Javier
Díaz de León Gómez, Ramón Enrique
Saade, Hened
López, Raúl G.
Valdez-Garza, Janett
López-Muñoz, R.
Treviño, M. E.
Morales, G.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nanoparticles of the poly(methyl methacrylate-co-methacrylic acid) or copolymer of P(MMA-co-MAA), were prepared by semicontinuous heterophase polymerization; they show a mean diameter of 12 nm and a 1.75 MMA/MAA molar ratio determined by carbon-13 nuclear magnetic resonance.
The content of MAA, greater than that of Eudragit S100, copolymer of P(MMA-co-MAA) accepted by the FDA for the preparation of tablets, ensures its biocompatibility and its metabolism without toxic effects.
Loaded with up to 22 wt.
% aspirin, that is, acetylsalicylic acid (ASA), these nanoparticles increase slightly their size, according to transmission electron microscopy; however, the presence of ASA on the nanoparticle surface decreases their stability, which leads to a certain aggregation of the particles in the dispersion.
Fourier transform infrared spectrometry was used for demonstrating the loading of ASA in the nanoparticles.
American Psychological Association (APA)
López-Muñoz, R.& Treviño, M. E.& Morales, G.& Valdez-Garza, Janett& Díaz de León Gómez, Ramón Enrique& Saade, Hened…[et al.]. 2019. Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1182018
Modern Language Association (MLA)
López-Muñoz, R.…[et al.]. Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin. Journal of Nanomaterials No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1182018
American Medical Association (AMA)
López-Muñoz, R.& Treviño, M. E.& Morales, G.& Valdez-Garza, Janett& Díaz de León Gómez, Ramón Enrique& Saade, Hened…[et al.]. Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1182018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182018