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Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis
Joint Authors
Blankenberg, Stefan
Lindner, Diana
Klingel, Karin
Westermann, Dirk
Gotzhein, Frauke
Becher, Peter Moritz
Escher, Felicitas
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Infection with Coxsackievirus B3 induces myocarditis.
We aimed to compare the acute and chronic phases of viral myocarditis to identify the immediate effects of cardiac inflammation as well as the long-term effects after resolved inflammation on cardiac fibrosis and consequently on cardiac function.
Material and Methods.
We infected C57BL/6J mice with Coxsackievirus B3 and determined the hemodynamic function 7 as well as 28 days after infection.
Subsequently, we analyzed viral burden and viral replication in the cardiac tissue as well as the expression of cytokines and matrix proteins.
Furthermore, cardiac fibroblasts were infected with virus to investigate if viral infection alone induces profibrotic signaling.
Results.
Severe cardiac inflammation was determined and cardiac fibrosis was consistently colocalized with inflammation during the acute phase of myocarditis.
Declined cardiac inflammation but no significantly improved hemodynamic function was observed 28 days after infection.
Interestingly, cardiac fibrosis declined to basal levels as well.
Both cardiac inflammation and fibrosis were reversible, whereas the hemodynamic function remains impaired after healed viral myocarditis in C57BL/6J mice.
American Psychological Association (APA)
Becher, Peter Moritz& Gotzhein, Frauke& Klingel, Karin& Escher, Felicitas& Blankenberg, Stefan& Westermann, Dirk…[et al.]. 2017. Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1182019
Modern Language Association (MLA)
Becher, Peter Moritz…[et al.]. Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis. Journal of Immunology Research No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1182019
American Medical Association (AMA)
Becher, Peter Moritz& Gotzhein, Frauke& Klingel, Karin& Escher, Felicitas& Blankenberg, Stefan& Westermann, Dirk…[et al.]. Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1182019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182019