![](/images/graphics-bg.png)
Desensitization: Overcoming the Immunologic Barriers to Transplantation
Joint Authors
Toyoda, Mieko
Vo, Ashley
Choi, Jua
Peng, Alice
Jordan, Stanley C.
Sethi, Supreet
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation.
It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after transplant.
Over the last decade, several immunomodulatory therapies have emerged allowing for increased access to kidney transplantation for the immunologically disadvantaged group of HLA sensitized end stage kidney disease patients.
These include IgG inactivating agents, anti-cytokine antibodies, costimulatory molecule blockers, complement inhibitors, and agents targeting plasma cells.
In this review, we discuss currently available agents for desensitization and provide a brief analysis of data on novel biologics, which will likely improve desensitization outcomes, and have potential implications in treatment of antibody mediated rejection.
American Psychological Association (APA)
Sethi, Supreet& Choi, Jua& Toyoda, Mieko& Vo, Ashley& Peng, Alice& Jordan, Stanley C.. 2017. Desensitization: Overcoming the Immunologic Barriers to Transplantation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182023
Modern Language Association (MLA)
Sethi, Supreet…[et al.]. Desensitization: Overcoming the Immunologic Barriers to Transplantation. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1182023
American Medical Association (AMA)
Sethi, Supreet& Choi, Jua& Toyoda, Mieko& Vo, Ashley& Peng, Alice& Jordan, Stanley C.. Desensitization: Overcoming the Immunologic Barriers to Transplantation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182023