Th1Th2 Balance and Th17Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis
Joint Authors
Zhu, Junfeng
Yang, Fangli
Sang, Lixuan
Li, Yan
Sun, Xun
Wang, Danan
Wang, Jinyan
Wei, Bing
Lu, Changlong
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood.
Methods.
We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge.
Results.
DSS-resistant BALB/c mice were characterized by low levels of IFN-γ and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice.
Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis.
Conclusions.
The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.
American Psychological Association (APA)
Yang, Fangli& Wang, Danan& Li, Yan& Sang, Lixuan& Zhu, Junfeng& Wang, Jinyan…[et al.]. 2017. Th1Th2 Balance and Th17Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182050
Modern Language Association (MLA)
Yang, Fangli…[et al.]. Th1Th2 Balance and Th17Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1182050
American Medical Association (AMA)
Yang, Fangli& Wang, Danan& Li, Yan& Sang, Lixuan& Zhu, Junfeng& Wang, Jinyan…[et al.]. Th1Th2 Balance and Th17Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182050