CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells
Joint Authors
Rollins, Meagan R.
Gibbons Johnson, Rachel M.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Tumor cells are capable of limiting antitumor CD8+ T cell responses through their cell surface expression of PD-L1.
In addition to PD-1 expressed by CD8+ T cells, PD-L1 also binds to CD80 expressed by CD8+ T cells.
The influence of the PD-L1/CD80 interaction on CD8+ T cell function has not been fully characterized, so we sought to investigate the impact of the PD-L1/CD80 interaction on PD-L1-induced apoptosis of activated CD8+ T cells.
We found that CD8+ T cells that lacked CD80 expression got activated to the same extent as wild-type CD8+ T cells, but when cultured with anti-CD3 and PD-L1/Fc protein, activated CD8+ T cells that lacked CD80 expression survived better than activated wild-type CD8+ T cells.
These findings indicate that PD-L1 induces apoptosis in activated CD8+ T cells in part by signaling through CD80.
Thus, in the design and implementation of checkpoint blockade therapies that target PD-L1, it is essential that both binding partners for PD-L1, PD-1, and CD80 are considered.
American Psychological Association (APA)
Rollins, Meagan R.& Gibbons Johnson, Rachel M.. 2017. CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1182081
Modern Language Association (MLA)
Rollins, Meagan R.& Gibbons Johnson, Rachel M.. CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells. Journal of Immunology Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1182081
American Medical Association (AMA)
Rollins, Meagan R.& Gibbons Johnson, Rachel M.. CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1182081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182081