Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?
Joint Authors
Adamczyk-Sowa, Monika
Medrek, Aldona
Madej, Paulina
Michlicka, Wirginia
Dobrakowski, Pawel
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aim.
Evaluation of the impact of gut microflora on the pathophysiology of MS.
Results.
The etiopathogenesis of MS is not fully known.
Gut microbiota may be of a great importance in the pathogenesis of MS, since recent findings suggest that substitutions of certain microbial population in the gut can lead to proinflammatory state, which can lead to MS in humans.
In contrast, other commensal bacteria and their antigenic products may protect against inflammation within the central nervous system.
The type of intestinal flora is affected by antibiotics, stress, or diet.
The effects on MS through the intestinal microflora can also be achieved by antibiotic therapy and Lactobacillus.
EAE, as an animal model of MS, indicates a strong influence of the gut microbiota on the immune system and shows that disturbances in gut physiology may contribute to the development of MS.
Conclusions.
The relationship between the central nervous system, the immune system, and the gut microbiota relates to the influence of microorganisms in the development of MS.
A possible interaction between gut microbiota and the immune system can be perceived through regulation by the endocannabinoid system.
It may offer an opportunity to understand the interaction comprised in the gut-immune-brain axis.
American Psychological Association (APA)
Adamczyk-Sowa, Monika& Medrek, Aldona& Madej, Paulina& Michlicka, Wirginia& Dobrakowski, Pawel. 2017. Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1182092
Modern Language Association (MLA)
Adamczyk-Sowa, Monika…[et al.]. Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?. Journal of Immunology Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1182092
American Medical Association (AMA)
Adamczyk-Sowa, Monika& Medrek, Aldona& Madej, Paulina& Michlicka, Wirginia& Dobrakowski, Pawel. Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1182092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182092