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Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models
Joint Authors
Li, Wen
Chen, Zhi-Hua
Huang, Gang
Xu, Xu-Chen
Zhou, Jie-Sen
Li, Zhou-Yang
Chen, Hai-Pin
Wang, Yong
Shen, Hua-Hao
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, which is characterized by chronic bronchitis, destruction of small airways, and enlargement/disorganization of alveoli.
It is generally accepted that the neutrophilic airway inflammation observed in the lungs of COPD patients is intrinsically linked to the tissue destruction and alveolar airspace enlargement, leading to disease progression.
Animal models play an important role in studying the underlying mechanisms of COPD as they address questions involving integrated whole body responses.
This review aims to summarize the current animal models of COPD, focusing on their advantages and disadvantages on immune responses and neutrophilic inflammation.
Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation.
American Psychological Association (APA)
Huang, Gang& Xu, Xu-Chen& Zhou, Jie-Sen& Li, Zhou-Yang& Chen, Hai-Pin& Wang, Yong…[et al.]. 2017. Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182094
Modern Language Association (MLA)
Huang, Gang…[et al.]. Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1182094
American Medical Association (AMA)
Huang, Gang& Xu, Xu-Chen& Zhou, Jie-Sen& Li, Zhou-Yang& Chen, Hai-Pin& Wang, Yong…[et al.]. Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182094