Biomedical Potentialities of Silver Nanoparticles for Clinical Multiple Drug-Resistant Acinetobacter baumannii

Abstract EN

Multidrug-resistant A.

baumannii is increasingly recognized as a significant problem in hospitals and causes high morbidity and mortality.

Here, we studied the antibacterial effects of AgNPs on clinically isolated multiple drug-resistant A.

baumannii, and search for the potential antibacterial mechanism.

Based on the results from the colony-forming unit (CFU) method, flow cytometry (FC), and a BrdU ELISA, we conclude that AgNPs can simultaneously induce apoptosis and inhibit new DNA synthesis in bacteria in a concentration-dependent manner.

This study presents the first discussion of an antibacterial effect by AgNPs in clinically isolated, multidrug-resistant A.

Baumannii and provides a new strategy for the use of silver nanoparticles in the multidrug-resistant A.

Baumannii clinical problem.