Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells
Joint Authors
Zhao, Li-Chun
Tang, Mei
Zhang, Qian-Hua
Hu, Zhi-Yi
Gao, Hong-Wei
Liao, Xia-Yun
Wang, Gang
Leng, Jing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
As an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery.
In this study, a new porous MOF, [[Dy2(H2O)3(SDBA)3](DMA)6] (1, H2SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N,N-dimethylacetamide (C4H9NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition.
The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement.
Due to the suitable window size and polar atom functionalized 1D channels, the activated 1 (1a) compound was used for the anticancer drug 5-fluorouracil (5-Fu, C4H3FN2O2) loading by a simple impregnation method.
A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a.
Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63.
American Psychological Association (APA)
Zhao, Li-Chun& Tang, Mei& Zhang, Qian-Hua& Hu, Zhi-Yi& Gao, Hong-Wei& Liao, Xia-Yun…[et al.]. 2018. Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1182131
Modern Language Association (MLA)
Zhao, Li-Chun…[et al.]. Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells. Journal of Chemistry No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1182131
American Medical Association (AMA)
Zhao, Li-Chun& Tang, Mei& Zhang, Qian-Hua& Hu, Zhi-Yi& Gao, Hong-Wei& Liao, Xia-Yun…[et al.]. Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1182131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182131