Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications
Joint Authors
Zhang, Chao
Wang, Shuo
Rong, Ruiming
Wang, Jina
Xu, Ming
Zhu, Dong
Yang, Cheng
Zhu, Tongyu
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Antibody-mediated rejection (AMR) has been identified as a main obstacle for stable immune tolerance and long survival of kidney allografts.
In spite of new insights into the underlying mechanisms of AMR, accurate diagnosis and efficient treatment are still challenges in clinical practice.
Endothelium is the first barrier between recipients’ immune systems and grafts in vascularized organ transplants.
Considering that endothelial cells express a number of antigens that can be attacked by various allo- and autoantibodies, endothelial cells act as main targets for the recipients’ humoral immune responses.
Importantly, emerging evidence has shown that endothelial cells in transplants could also initiate protective mechanisms in response to immune injuries.
A better understanding of the role of endothelial cells during the pathogenesis of AMR might provide novel therapeutic targets.
In the present review, we summarize the antigens expressed by endothelial cells and also discuss the activation and accommodation of endothelial cells as well as their clinical implications.
Collectively, the progress discussed in this review indicates endothelial cells as promising targets to improve current diagnosis and therapeutic regimens for AMR.
American Psychological Association (APA)
Wang, Shuo& Zhang, Chao& Wang, Jina& Yang, Cheng& Xu, Ming& Rong, Ruiming…[et al.]. 2017. Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182180
Modern Language Association (MLA)
Wang, Shuo…[et al.]. Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1182180
American Medical Association (AMA)
Wang, Shuo& Zhang, Chao& Wang, Jina& Yang, Cheng& Xu, Ming& Rong, Ruiming…[et al.]. Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182180