Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae
Joint Authors
LeMessurier, Kim S.
Samarasinghe, Amali E.
Michael, Christie F.
Waters, Christopher M.
Song, Chi Y.
Malik, Kafait U.
Lew, D. Betty
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In asthmatic airways, repeated epithelial damage and repair occur.
No current therapy directly targets this process.
We aimed to determine the effects of mannan derived from S.
cerevisiae (SC-MN) on airway epithelial wound repair, in vitro.
The presence of functional mannose receptors in bronchial epithelial cells was shown by endocytosis of colloidal gold-Man BSA via clathrin-coated pits in 16HBE cells.
In primary normal human bronchial epithelial cells (NHBEC), SC-MN significantly facilitated wound closure.
Treatment with SC-MN stimulated cell spreading as indicated by a significant increase in the average lamellipodial width of wound edge 16HBE cells.
In addition, NHBEC treated with SC-MN showed increased expression and activation of Krüppel-like factors (KLFs) 4 and 5, transcription factors important in epithelial cell survival and regulation of epithelial-mesenchymal transition.
We conclude that SC-MN facilitates wound repair in human bronchial epithelium, involving mannose receptors.
American Psychological Association (APA)
Michael, Christie F.& Waters, Christopher M.& LeMessurier, Kim S.& Samarasinghe, Amali E.& Song, Chi Y.& Malik, Kafait U.…[et al.]. 2017. Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1182190
Modern Language Association (MLA)
Michael, Christie F.…[et al.]. Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1182190
American Medical Association (AMA)
Michael, Christie F.& Waters, Christopher M.& LeMessurier, Kim S.& Samarasinghe, Amali E.& Song, Chi Y.& Malik, Kafait U.…[et al.]. Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1182190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182190