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Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review
Joint Authors
Brankovic, Ivan
Ouburg, Sander
Morré, Servaas A.
Jordanova, E. S.
Mehta, Akash M.
Mooij, Merel
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (HPV) infections.
Genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients.
We reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions with risk and progression of cervical cancer.
Studies on HLA and KIR gene polymorphisms were excluded due to the abundance on literature on that subject.
We show that multiple genes and loci are associated with variation in risk of cervical cancer.
Rather than one single gene being responsible for cervical carcinogenesis, we postulate that variations in the different immune response genes lead to subtle differences in the effectiveness of the antiviral and antitumour immune responses, ultimately leading to differences in risk of developing cervical cancer and progressive disease after HPV infection.
American Psychological Association (APA)
Mehta, Akash M.& Mooij, Merel& Brankovic, Ivan& Ouburg, Sander& Morré, Servaas A.& Jordanova, E. S.. 2017. Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182195
Modern Language Association (MLA)
Mehta, Akash M.…[et al.]. Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1182195
American Medical Association (AMA)
Mehta, Akash M.& Mooij, Merel& Brankovic, Ivan& Ouburg, Sander& Morré, Servaas A.& Jordanova, E. S.. Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182195