MCM-41-Accelerated PWA Catalysis of Friedel-Crafts Reaction of Indoles and Isatins

Abstract EN

Ordered mesoporous siliceous material has been identified as one of the key elements of the catalysis concept.

Here we report an efficient Friedel-Crafts reaction of indoles with isatins catalyzed by PWA/MCM-41, which got the di(indolyl)indolin-2-ones derivatives with high yield.

Moreover, the catalysts were characterized by XRD and SEM/EDS, the EDS spectrum indicated that the catalyst used in this reaction also contains tungsten, and the proposed mechanism for the synthesis of 3,3-di(indolyl)indolin-2-ones was also discussed.

Finally, the catalyst can be reused repeatedly for several times without obvious loss of activity.