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Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus
Joint Authors
Lafuente, Esther M.
Alonso-Padilla, Julio
Reche, Pedro A.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Epstein-Barr virus is a very common human virus that infects 90% of human adults.
EBV replicates in epithelial and B cells and causes infectious mononucleosis.
EBV infection is also linked to various cancers, including Burkitt’s lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis.
Currently, there are no effective drugs or vaccines to treat or prevent EBV infection.
Herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemble from experimentally defined T and B cell epitopes.
Such strategy relies on identifying conserved epitopes in conjunction with predictions of HLA presentation for T cell epitope selection and calculations of accessibility and flexibility for B cell epitope selection.
The T cell component includes 14 CD8 T cell epitopes from early antigens and 4 CD4 T cell epitopes, targeted during the course of a natural infection and providing a population protection coverage of over 95% and 81.8%, respectively.
The B cell component consists of 3 experimentally defined B cell epitopes from gp350 plus 4 predicted B cell epitopes from other EBV envelope glycoproteins, all mapping in flexible and solvent accessible regions.
We discuss the rationale for the formulation and possible deployment of this epitope vaccine ensemble.
American Psychological Association (APA)
Alonso-Padilla, Julio& Lafuente, Esther M.& Reche, Pedro A.. 2017. Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1182247
Modern Language Association (MLA)
Alonso-Padilla, Julio…[et al.]. Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus. Journal of Immunology Research No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1182247
American Medical Association (AMA)
Alonso-Padilla, Julio& Lafuente, Esther M.& Reche, Pedro A.. Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1182247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182247