Neutrophils and Immunity: From Bactericidal Action to Being Conquered
Joint Authors
Li, Yanzhang
Ji, Xinying
Teng, Tie-Shan
Ji, Ailing
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The neutrophil is the major phagocyte and the final effector cell of the innate immunity, with a primary role in the clearance of extracellular pathogens.
Using the broad array of cytokines, extracellular traps, and effector molecules as the humoral arm, neutrophils play a crucial role in the host defense against pathogen infections.
On the other hand, the pathogen has the capacity to overcome neutrophil-mediated host defense to establish infection causing human disease.
Pathogens, such as S.
aureus, have the potential to thwart neutrophil chemotaxis and phagocytosis and thereby succeed in evading killing by neutrophils.
Furthermore, S.
aureus surviving within neutrophils promotes neutrophil cytolysis, resulting in the release of host-derived molecules that promote local inflammation.
Here, we provide a detailed overview of the mechanisms by which neutrophils kill the extracellular pathogens and how pathogens evade neutrophils degradation.
This review will provide insights that might be useful for the development of novel therapies against infections caused by antibiotic resistant pathogens.
American Psychological Association (APA)
Teng, Tie-Shan& Ji, Ailing& Ji, Xinying& Li, Yanzhang. 2017. Neutrophils and Immunity: From Bactericidal Action to Being Conquered. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1182272
Modern Language Association (MLA)
Teng, Tie-Shan…[et al.]. Neutrophils and Immunity: From Bactericidal Action to Being Conquered. Journal of Immunology Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1182272
American Medical Association (AMA)
Teng, Tie-Shan& Ji, Ailing& Ji, Xinying& Li, Yanzhang. Neutrophils and Immunity: From Bactericidal Action to Being Conquered. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1182272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182272