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Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates
Joint Authors
Elsayed, Elsayed A.
El-Naggar, Mohamed
El-Shorbagi, Abdel-Nasser
Elnaggar, Dina H.
Amr, Abd El-Galil E.
al-Omar, Mohamed A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents.
Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were treated with substituted imino or substituted amino derivatives, to give the corresponding substituted amino-pent-2-en-3-yl-diazenylbenzoate 4a–k or 2-substituted-1-(naphthalen-1-yl)diazene derivatives 6a–h, 7a,b, and 8a,b.
All the synthesized compounds were elucidated by elemental analysis and spectroscopic evidence.
American Psychological Association (APA)
El-Naggar, Mohamed& El-Shorbagi, Abdel-Nasser& Elnaggar, Dina H.& Amr, Abd El-Galil E.& al-Omar, Mohamed A.& Elsayed, Elsayed A.. 2018. Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1182283
Modern Language Association (MLA)
El-Naggar, Mohamed…[et al.]. Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates. Journal of Chemistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1182283
American Medical Association (AMA)
El-Naggar, Mohamed& El-Shorbagi, Abdel-Nasser& Elnaggar, Dina H.& Amr, Abd El-Galil E.& al-Omar, Mohamed A.& Elsayed, Elsayed A.. Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1182283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182283