Enhancing Biocompatibility without Compromising Material Properties: An Optimised NaOH Treatment for Electrospun Polycaprolactone Fibres
Joint Authors
Bosworth, Lucy A.
Hu, Wanxiao
Shi, Yingnan
Cartmell, S.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This research presents the first optimised protocol for submersion of electrospun polycaprolactone (PCL) fibres in sodium hydroxide (NaOH) to improve surface hydrophilicity, and hence biocompatibility, without compromising material properties.
The study comprised two aims: (1) identify the leading NaOH concentration (0, 0.1, 1, and 10 M) and submersion time (0, 1, 4, and 24 h) to improve hydrophilicity with minimal impact on tensile properties and (2) once identified, undertake material characterisation and in vitro testing for validation.
1 M 4 h (NaOH concentration: 1 M, submersion time: 4 h) improved hydrophilicity (aligned fibres at 0 M NaOH and 0 h submersion time reduced from 97±3° to 6±2°; and random fibres at 0 M 0 h reduced from 105±4° to 15±7°) with minimal impact on tensile strength (9% and 6% loss aligned and random, respectively).
1 M 4 h-treated scaffolds demonstrated no significant change in material properties, yet notably improved protein adsorption and attachment, viability and elongation of 3T3 fibroblasts 4 h postseeding.
Thus, 1 M 4 h is optimal for successful wet chemical treatment of electrospun PCL and presents a simple and economical method to easily enhance biocompatibility without compromising scaffold integrity.
American Psychological Association (APA)
Bosworth, Lucy A.& Hu, Wanxiao& Shi, Yingnan& Cartmell, S.. 2019. Enhancing Biocompatibility without Compromising Material Properties: An Optimised NaOH Treatment for Electrospun Polycaprolactone Fibres. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1182293
Modern Language Association (MLA)
Bosworth, Lucy A.…[et al.]. Enhancing Biocompatibility without Compromising Material Properties: An Optimised NaOH Treatment for Electrospun Polycaprolactone Fibres. Journal of Nanomaterials No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1182293
American Medical Association (AMA)
Bosworth, Lucy A.& Hu, Wanxiao& Shi, Yingnan& Cartmell, S.. Enhancing Biocompatibility without Compromising Material Properties: An Optimised NaOH Treatment for Electrospun Polycaprolactone Fibres. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1182293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182293