Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL
Joint Authors
Kimmel, Danielle W.
Dole, William P.
Cliffel, David E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Atherogenesis is the narrowing of arteries due to plaque build-up that results in cardiovascular disease that can lead to death.
The macrophage lectin-like oxidized LDL receptor-1 (LOX-1), also called the oxidized low-density lipoprotein receptor 1 (OLR1), is currently thought to aid in atherosclerotic disease progression; therefore metabolic studies have potential to both provide mechanistic validation for the role of LOX-1 in disease progression and provide valuable information regarding biomarker strategies and clinical imaging.
One such mechanistic study is the upregulation of LOX-1 by methylated bacterial DNA and deoxy-cytidylate-phosphate-deoxy-guanylate-DNA (CpG)-DNA exposure.
CpG-DNA is known to promote oxidative burst responses in macrophages, due to its direct binding to toll-like receptor 9 (TLR9) leading to the initiation of an NF-κB mediated immune response.
In addition to the upregulation of macrophage LOX-1 expression, these studies have also examined the macrophage metabolic response to murine LOX-1/OLR1 antibody exposure.
Our data suggests the antibody exposure effectively blocks LOX-1 dependent oxLDL metabolic activation of the macrophage, which was quantified using the multianalyte microphysiometer (MAMP).
Using the MAMP to examine metabolic fluctuations during various types of oxLDL exposure, LOX-1 upregulation and inhibition provide valuable information regarding the role of LOX-1 in macrophage activation of oxidative burst.
American Psychological Association (APA)
Kimmel, Danielle W.& Dole, William P.& Cliffel, David E.. 2017. Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL. Journal of Lipids،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182323
Modern Language Association (MLA)
Kimmel, Danielle W.…[et al.]. Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL. Journal of Lipids No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1182323
American Medical Association (AMA)
Kimmel, Danielle W.& Dole, William P.& Cliffel, David E.. Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL. Journal of Lipids. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182323