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Design, Synthesis, and Anticancer Activities of Novel 2-Amino-4-phenylthiazole Scaffold Containing Amide Moieties
Joint Authors
Zhang, Zhi-Hua
Wu, Hong-Mei
Deng, Sai-Nan
Cai, Xiao-Yu
Yao, Yu
Mwenda, Muriira Cyrus
Wang, Jin-Yin
Cai, Dong
Chen, Yu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Appropriately substituted 2-amino-4-phenylthiazole derivatives were designed and synthesized according to the structural characteristics of crizotinib.
The obtained compounds were characterized using 1H NMR, 13C NMR, and HRMS.
The target compounds 5a–o were evaluated for their in vitro antiproliferative activity against A549, HeLa, HT29, and Karpas299 human cancer cell lines.
Based on results of biological studies, some of these compounds exhibited significant antiproliferative activity.
Compound 5b possessed outstanding growth inhibitory effects on the four cell lines, especially for HT29 cell with IC50 value of 2.01 µM.
Along with the biological assay data, a molecular docking study suggests that the target compounds were a potential inhibitor.
American Psychological Association (APA)
Zhang, Zhi-Hua& Wu, Hong-Mei& Deng, Sai-Nan& Cai, Xiao-Yu& Yao, Yu& Mwenda, Muriira Cyrus…[et al.]. 2018. Design, Synthesis, and Anticancer Activities of Novel 2-Amino-4-phenylthiazole Scaffold Containing Amide Moieties. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182335
Modern Language Association (MLA)
Zhang, Zhi-Hua…[et al.]. Design, Synthesis, and Anticancer Activities of Novel 2-Amino-4-phenylthiazole Scaffold Containing Amide Moieties. Journal of Chemistry No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1182335
American Medical Association (AMA)
Zhang, Zhi-Hua& Wu, Hong-Mei& Deng, Sai-Nan& Cai, Xiao-Yu& Yao, Yu& Mwenda, Muriira Cyrus…[et al.]. Design, Synthesis, and Anticancer Activities of Novel 2-Amino-4-phenylthiazole Scaffold Containing Amide Moieties. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182335