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Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors
Joint Authors
Onul, Nihal
Ertik, Onur
Mermer, Neşe
Yanardag, Refiye
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
S-substituted perhalo-2-nitrobuta-1,3-dienes 3a, b were synthesized by the reaction of polyhalo-2-nitrobuta-1,3-dienes 1a, b with allyl mercaptan.
1-(2,3-Dibromopropanethio)-4-bromo-1,3,4-trichloro-2-nitrobuta-1,3-diene 4 was obtained from the addition of bromine to S-substituted polyhalo-2-nitrobuta-1,3-diene 3b in carbon tetrachloride.
Sulfoxides 5a, b, and 6 were obtained from the reaction of thiosubstituted polyhalonitrobutadienes 3a, b, and 4 with m-CPBA in CHCl3.
The structures of the new compounds were determined by spectroscopic data (FTIR, 1H NMR, 13C NMR, MS).
These compounds exhibited antixanthine oxidase, antityrosinase, antielastase, and antineuraminidase activities.
American Psychological Association (APA)
Onul, Nihal& Ertik, Onur& Mermer, Neşe& Yanardag, Refiye. 2018. Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1182349
Modern Language Association (MLA)
Onul, Nihal…[et al.]. Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors. Journal of Chemistry No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1182349
American Medical Association (AMA)
Onul, Nihal& Ertik, Onur& Mermer, Neşe& Yanardag, Refiye. Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1182349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182349