Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

Joint Authors

Onul, Nihal
Ertik, Onur
Mermer, Neşe
Yanardag, Refiye

Source

Journal of Chemistry

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-01-31

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Chemistry

Abstract EN

S-substituted perhalo-2-nitrobuta-1,3-dienes 3a, b were synthesized by the reaction of polyhalo-2-nitrobuta-1,3-dienes 1a, b with allyl mercaptan.

1-(2,3-Dibromopropanethio)-4-bromo-1,3,4-trichloro-2-nitrobuta-1,3-diene 4 was obtained from the addition of bromine to S-substituted polyhalo-2-nitrobuta-1,3-diene 3b in carbon tetrachloride.

Sulfoxides 5a, b, and 6 were obtained from the reaction of thiosubstituted polyhalonitrobutadienes 3a, b, and 4 with m-CPBA in CHCl3.

The structures of the new compounds were determined by spectroscopic data (FTIR, 1H NMR, 13C NMR, MS).

These compounds exhibited antixanthine oxidase, antityrosinase, antielastase, and antineuraminidase activities.

American Psychological Association (APA)

Onul, Nihal& Ertik, Onur& Mermer, Neşe& Yanardag, Refiye. 2018. Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1182349

Modern Language Association (MLA)

Onul, Nihal…[et al.]. Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors. Journal of Chemistry No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1182349

American Medical Association (AMA)

Onul, Nihal& Ertik, Onur& Mermer, Neşe& Yanardag, Refiye. Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1182349

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1182349