Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent
Joint Authors
Mohamed Isa, Eleen Dayana
Ahmad, Haslina
Abdul Rahman, Mohd Basyaruddin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Optimization is a process utilized to discover the best condition to generate the best possible outcome.
One of the common optimization method used in the field of chemistry is response surface methodology (RSM).
This method consists of mathematical and statistical techniques which relate the responses with the variables of interest.
There are many experimental designs in RSM, and one of the most common one is the Box-Behnken design (BBD).
In this work, BBD was employed to analyze the main effects and interactions of the reaction temperature, amount of template, and amount of triethanolamine (TEA) on the two responses which are the surface area (SA) and particle size (PS) of ionic liquid templated mesoporous silica nanoparticles (MSNs).
It was found that the SA and PS were fitted with linear and quadratic models, respectively.
MSNs with the highest surface area (999.051 m2 g-1) was chosen for the application of drug delivery; thus, drug loading and drug release experiments were conducted.
From these studies, it was found that 37% of drug (quercetin) was successfully encapsulated in MSN and, in 48 hours, 32% of the drug was released.
American Psychological Association (APA)
Mohamed Isa, Eleen Dayana& Ahmad, Haslina& Abdul Rahman, Mohd Basyaruddin. 2019. Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1182410
Modern Language Association (MLA)
Mohamed Isa, Eleen Dayana…[et al.]. Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent. Journal of Nanomaterials No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1182410
American Medical Association (AMA)
Mohamed Isa, Eleen Dayana& Ahmad, Haslina& Abdul Rahman, Mohd Basyaruddin. Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1182410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182410