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L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A study was planned to synthesize the phthalimide derivatives as phthalimides have versatile biological activities.
To synthesize the phthalimide derivatives, initially the reaction was optimized with various catalysts, and L-proline was found to be the best catalyst as it provided excellent yield.
A series of phthalimide derivatives was synthesized by facile one-top reaction of phthalic acid with aryl amines under mild reaction conditions in the presence of L-proline as catalyst.
Products were obtained in excellent yields and structurally characterized by 1H, 13C NMR, and mass spectral data.
Products 1–7 were evaluated for antioxidant, anti-inflammatory, and lipoxygenase enzyme inhibition activities.
Compounds 1 and 4 showed potent antioxidant activity under DPPH with IC50 values 27.3 and 25.0 μM when compared with the standard BHA (IC50 = 44.2 μM), respectively.
Compounds 1 and 4 further showed strong lipoxygenase inhibition activity with IC50 values 21.34 and 20.45 μM when compared with standard baicalein (IC50 = 22.60 μM), respectively.
Compound 2 was found to be promising and about equal to the used standard aspirin in the inhibition of bovine serum albumin denaturation, while other compounds showed weak-to-moderate % inhibition.
American Psychological Association (APA)
Perveen, Shagufta& Orfali, Raha. 2018. L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1182413
Modern Language Association (MLA)
Perveen, Shagufta& Orfali, Raha. L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities. Journal of Chemistry No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1182413
American Medical Association (AMA)
Perveen, Shagufta& Orfali, Raha. L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1182413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182413