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On the Helical Structure of Guanosine 5′-Monophosphate Formed at pH 5: Is It Left- or Right-Handed?
Joint Authors
Huang, Yining
Wu, Gang
Kwan, Irene C. M.
Yan, Zhimin
Ye, Eric
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Early X-ray fiber diffraction studies have established that the spontaneous gel formation of guanosine 5′-monophosphate (5′-GMP) under slightly acidic conditions (e.g., pH 5) results from self-assembly of 5′-GMP into a helical structure in which hydrogen-bonded guanine bases form a continuous helix with 15 nucleotides per 4 turns.
For more than five decades, the sense of this helix is believed to be left-handed.
Using multinuclear solid-state NMR and IR spectroscopic methods, we have finally determined the long-missing structural details of this helix.
First, we found that this 5′-GMP helix is right-handed containing exclusive C3′-endo sugar puckers.
Second, we showed that the central channel of this helix is free of Na+ ions, which is in sharp contrast to the helix formed by 5′-GMP at pH 8 where the central channel is filled with Na+ ions.
American Psychological Association (APA)
Wu, Gang& Kwan, Irene C. M.& Yan, Zhimin& Huang, Yining& Ye, Eric. 2017. On the Helical Structure of Guanosine 5′-Monophosphate Formed at pH 5: Is It Left- or Right-Handed?. Journal of Nucleic Acids،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1182471
Modern Language Association (MLA)
Wu, Gang…[et al.]. On the Helical Structure of Guanosine 5′-Monophosphate Formed at pH 5: Is It Left- or Right-Handed?. Journal of Nucleic Acids No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1182471
American Medical Association (AMA)
Wu, Gang& Kwan, Irene C. M.& Yan, Zhimin& Huang, Yining& Ye, Eric. On the Helical Structure of Guanosine 5′-Monophosphate Formed at pH 5: Is It Left- or Right-Handed?. Journal of Nucleic Acids. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1182471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182471